Self-crowding induced phase separation in protein dispersions

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Self-crowding induced phase separation in protein dispersions.

The coupling between protein conformation, molecular volume, and solution phase behaviour is studied theoretically for a two-state, coarse-grained protein model in which protein molecules can reversibly switch between a native and a non-native excited state. In the model, native and non-native conformers are represented by perfect spheres with different hard-core diameters. We presume the large...

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ژورنال

عنوان ژورنال: The Journal of Chemical Physics

سال: 2015

ISSN: 0021-9606,1089-7690

DOI: 10.1063/1.4922927